三氟乙醇的介绍

增加分子脂溶性。三氟乙醇是一种有机化合物，缩写为TFE，它是无色、能与水相溶的液体，三氟乙醇在烷基化中的作用增加分子脂溶性，提高药效或降低生物体的毒副作用，由其合成的药物主要有中枢神经兴奋剂氟替尔。

灰色格子里从上到下分别为：化学式、摩尔质量、外观（无色液体）、密度、熔点、沸点、水中溶解度（与水混溶）、乙醇中溶解度（与乙醇混溶）、酸性(pKa)、粘度、标准摩尔熵、标准摩尔生成焓、标准摩尔燃烧焓

EMERGENCY OVERVIEW

Flammable. Harmful by inhalation, in contact with skin and if

swallowed. Irritating to eyes and skin. Possible risk of impaired

fertility.

Potential Health Effects

Eye:

Causes eye irritation.

Skin:

Causes skin irritation. Harmful if absorbed through the skin.

Ingestion:

Harmful if swallowed. May cause irritation of the digestive tract.

Inhalation:

Harmful if inhaled. May cause respiratory tract irritation.

Chronic:

Not available.

**** SECTION 4 - FIRST AID MEASURES ****

Eyes:

Flush eyes with plenty of water for at least 15 minutes,

occasionally lifting the upper and lower eyelids. Get medical aid.

Skin:

Get medical aid. Flush skin with plenty of water for at least 15

minutes while removing contaminated clothing and shoes.

Ingestion:

Get medical aid. If conscious drink water, then induce vomiting. If

unconscious, immediately take victim to a physician and do NOT

attempt to induce vomiting.

Inhalation:

Remove from exposure and move to fresh air immediately. If not

breathing, give artificial respiration. If breathing is difficult,

give oxygen. Get medical aid.

Notes to Physician:

**** SECTION 5 - FIRE FIGHTING MEASURES ****

General Information:

As in any fire, wear a self-contained breathing apparatus in

pressure-demand, MSHA/NIOSH (approved or equivalent), and full

protective gear. Vapors can travel to a source of ignition and flash

back. Will burn if involved in a fire. Flammable liquid and vapor.

Extinguishing Media:

Use water spray, dry chemical, carbon dioxide, or chemical foam.

**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

General Information: Use proper personal protective equipment as indicated

in Section 8.

Spills/Leaks:

Absorb spill with inert material (e.g. vermiculite, sand or earth),

then place in suitable container. Remove all sources of ignition.

Use a spark-proof tool.

**** SECTION 7 - HANDLING and STORAGE ****

Handling:

Use spark-proof tools and explosion proof equipment. Avoid breathing

dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only

in a chemical fume hood.

Storage:

Keep away from sources of ignition. Store in a cool, dry place.

Store in a tightly closed container. Flammables-area.

**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

Engineering Controls:

Facilities storing or utilizing this material should be equipped

with an eyewash facility and a safety shower. Use adequate

ventilation to keep airborne concentrations low.

Personal Protective Equipment

Eyes:

Wear chemical goggles.

Skin:

Wear appropriate protective gloves to prevent skin

exposure.

Clothing:

Wear appropriate protective clothing to prevent skin

exposure.

Respirators:

Follow the OSHA respirator regulations found in 29

CFR 1910.134 or European Standard EN 149. Always use

a NIOSH or European Standard EN 149 approved

respirator when necessary.

**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State: Clear liquid

Color: colorless

Odor: characteristic odor

pH: 5.0-7.5 (10% aq. sol.)

Vapor Pressure: 3.5hPa @20 deg C

Viscosity: 1.75 mPa.s @25 deg C

Boiling Point: 77 - 80 deg C @760mmHg

Freezing/Melting Point: -45 deg C

Autoignition Temperature: 480 deg C ( 896.00 deg F)

Flash Point:29 deg C ( 84.20 deg F)

Explosion Limits, lower:5.5

Explosion Limits, upper:42

Decomposition Temperature: 315 deg C

Solubility in water:miscible with water

Specific Gravity/Density: 1.390

Molecular Formula: C2H3F3O

Molecular Weight: 100.04

**** SECTION 10 - STABILITY AND REACTIVITY ****

Chemical Stability:

Stable under normal temperatures and pressures.

Conditions to Avoid:

Incompatible materials, ignition sources.

Incompatibilities with Other Materials:

Oxidizing agents, bases, alkali metals, alkaline earth metals,

potassium, sodium.

Hazardous Decomposition Products:

Carbon monoxide, irritating and toxic gases, carbon dioxide, hydrogen

fluoride gas.

Hazardous Polymerization: Has not been reported

**** SECTION 11 - TOXICOLOGICAL INFORMATION ****

RTECS#:

CAS# 75-89-8: KM5250000

LD50/LC50:

CAS# 75-89-8: Draize test, rabbit, eye: 20 mg/24H ModerateDraize

test, rabbit, skin: 750 ug/24H SevereInhalation, mouse: LC50 = 2900

mg/m3/2HInhalation, mouse: LC50 = 2900 mg/m3/2HInhalation, rat:

LC50 = 470 ppm/6HOral, mouse: LD50 = 366 mg/kgOral, rat: LD50 =

240 mg/kgSkin, rabbit: LD50 = 390 uL/kgSkin, rat: LD50 = 1680

mg/kg.

Carcinogenicity:

2,2,2-Trifluoroethanol -

Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.

See actual entry in RTECS for complete information.

**** SECTION 12 - ECOLOGICAL INFORMATION ****

Ecotoxicity:

Daphnia: >100 mg/l24Hlog Pow: 0.652

Other

Avoid entering into waters or underground water. Do not empty into

drains.

**** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

中午好，一般常见的PE、PS和PC一次性塑料试管都可以耐受三氟乙酸和三氟乙醇，但是不要用含氟高聚物如PVDF和PTFE的容器来盛放，它们都会缓慢侵蚀氟塑料的请酌情参考。这两种有机溶剂也不能用二氧化硅的无机玻璃来长期存储（可以耐高硼硅和铅玻璃）。

氯原子是吸引电子的取代基；甲基是排斥电子的取代基。

所以酸性顺序为：三氯乙醇>氯乙醇>乙醇>叔丁醇