二乙二醇二甲醚有没有毒

编号 毒性类型 测试方法 测试对象 使用剂量 毒性作用 1 acute Oral Human 3380 mg/kg 1.胃肠道毒性Gastrointestinal - gastritis2.肝毒性Liver - other changes3.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -other changes 2 acute Inhalation Human 25 ppm 1.行为毒性Behavioral - tremor2.行为毒性Behavioral - convulsions or effect on seizure threshold3.行为毒性Behavioral - changes in motor activity (specific assay) 3 acute Oral Rodent - rat 2370 mg/kg 1.行为毒性Behavioral - altered sleep time (including change in righting reflex)2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration -other changes 4 acute Inhalation Rodent - rat 1500 ppm/7H 1.Details of toxic effects not reported other than lethal dose value 5 acute Intraperitoneal Rodent - rat 2500 mg/kg 1.Details of toxic effects not reported other than lethal dose value 6 acute Intravenous Rodent - rat 2068 mg/kg 1.血液毒性Blood - other hemolysis with or without anemia 7 acute Oral Rodent - mouse 2560 mg/kg 1.行为毒性Behavioral - somnolence (general depressed activity)2.行为毒性Behavioral - changes in motor activity (specific assay)3.心脏毒性Cardiac - other changes 8 acute Inhalation Rodent - mouse 1480 ppm/7H 1.行为毒性Behavioral - analgesia2.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration -dyspnea3.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -hematuria 9 acute Intraperitoneal Rodent - mouse 2147 mg/kg 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -changes in both tubules and glomeruli2.血液毒性Blood - changes in spleen3.血液毒性Blood - other changes 10 acute Oral Rodent - rabbit 890 mg/kg 1.行为毒性Behavioral - general anesthetic2.血液毒性Blood - other hemolysis with or without anemia 11 acute Administration onto the skin Rodent - rabbit 1280 mg/kg 1.Details of toxic effects not reported other than lethal dose value 12 acute Oral Rodent - guinea pig 950 mg/kg 1.行为毒性Behavioral - general anesthetic2.胃肠道毒性Gastrointestinal - other changes3.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -other changes 13 MutipleDose Inhalation Rodent - rat 400 ppm/6H/2W-I 1.大脑毒性Brain and Coverings - other degenerative changes2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain3.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects 14 MutipleDose Oral Rodent - rat 10206 mg/kg/21D-C 1.内分泌毒性Endocrine - changes in thymus weight2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain3.慢性病相关毒性Related to Chronic Data - changes in testicular weight 15 MutipleDose Oral Rodent - rat 500 mg/kg/10D-I 1.内分泌毒性Endocrine - changes in thymus weight2.免疫系统毒性Immunological Including Allergic - decreased immune response 16 MutipleDose Inhalation Rodent - rat 300 ppm/6H/13W-I 1.血液毒性Blood - changes in leukocyte (WBC) count2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain3.慢性病相关毒性Related to Chronic Data - changes in testicular weight 17 MutipleDose Inhalation Rodent - rat 970 mg/m3/7H/5W-I 1.血液毒性Blood - changes in bone marrow (not otherwise specified)2.血液毒性Blood - changes in spleen 18 MutipleDose Inhalation Rodent - rat 1000 ppm/6H/11D-I 1.肾、输尿管和膀胱毒性Kidney, Ureter, Bladder -other changes in urine composition2.血液毒性Blood - changes in bone marrow (not otherwise specified)3.血液毒性Blood - changes in leukocyte (WBC) count 19 MutipleDose Administration onto the skin Rodent - rat 20 mg/kg/4W-I 1.血液毒性Blood - changes in other cell count (unspecified)2.血液毒性Blood - changes in leukocyte (WBC) count3.慢性病相关毒性Related to Chronic Data - changes in testicular weight 20 MutipleDose Intraperitoneal Rodent - rat 450 mg/kg/16D-I 1.血液毒性Blood - changes in other cell count (unspecified)2.生化毒性Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes 21 MutipleDose Oral Rodent - rat 29484 mg/kg/13W-C 1.内分泌毒性Endocrine - changes in thymus weight2.血液毒性Blood - changes in platelet count3.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain 22 MutipleDose Administration onto the skin Rodent - rat 3200 mg/kg/4D-I 1.内分泌毒性Endocrine - changes in thymus weight2.免疫系统毒性Immunological Including Allergic - decrease in humoral immune response 23 MutipleDose Oral Rodent - mouse 12110 mg/kg/2W-C 1.内分泌毒性Endocrine - changes in thymus weight2.慢性病相关毒性Related to Chronic Data - changes in testicular weight 24 MutipleDose Oral Rodent - mouse 82 mg/kg/13W-C 1.内分泌毒性Endocrine - effect on menstrual cycle2.内分泌毒性Endocrine - other changes3.血液毒性Blood - changes in spleen 25 MutipleDose Inhalation Rodent - mouse 1000 ppm/6H/11D-I 1.血液毒性Blood - changes in leukocyte (WBC) count2.慢性病相关毒性Related to Chronic Data - changes in testicular weight 26 MutipleDose Inhalation Mammal - dog 750 ppm/7H/12W-I 1.血液毒性Blood - microcytosis with or without anemia2.血液毒性Blood - other changes 27 MutipleDose Inhalation Rodent - rabbit 300 ppm/6H/13W-I 1.内分泌毒性Endocrine - changes in thymus weight2.血液毒性Blood - changes in erythrocyte (RBC) count3.慢性病相关毒性Related to Chronic Data - changes in testicular weight 28 MutipleDose Administration onto the skin Rodent - guinea pig 65 mg/kg/13W-I 1.血液毒性Blood - changes in erythrocyte (RBC) count2.营养和代谢系统毒性Nutritional and Gross Metabolic - weight loss or decreased weight gain3.慢性病相关毒性Related to Chronic Data - changes in testicular weight 29 SkinEyeIrrition Administration onto the skin Rodent - rabbit 483 mg/24H 1.Mild 30 SkinEyeIrrition Administration into the eye Rodent - rabbit 97 mg 31 SkinEyeIrrition Administration into the eye Rodent - rabbit 500 mg/24H 1.Mild 32 SkinEyeIrrition Administration into the eye Rodent - guinea pig 10 ug 1.Mild 33 Mutation Human Lymphocyte 150 mmol/L 34 Mutation Oral Rodent - rat 500 mg/kg 35 Mutation Oral Rodent - rat 500 mg/kg 36 Mutation Oral Rodent - mouse 500 mg/kg 37 Reproductive Oral Rodent - rat 175 mg/kg,female 7-13 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system 38 Reproductive Oral Rodent - rat 175 mg/kg,female 7-13 day(s) after conception 1.生殖毒性Reproductive - Maternal Effects - parturition2.生殖毒性Reproductive - Effects on Newborn -biochemical and metabolic 39 Reproductive Oral Rodent - rat 15015 mg/kg,male 13 week(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, andcount) 40 Reproductive Oral Rodent - rat 100 mg/kg,male 1 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct 41 Reproductive Oral Rodent - rat 350 mg/kg,female 9-15 day(s) after conception 1.生殖毒性Reproductive - Fertility -litter size (e.g. # fetuses per littermeasured before birth)2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus)3.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system 42 Reproductive Inhalation Rodent - rat 68 mg/kg/4H,female 1-19 day(s) after conception 1.生殖毒性Reproductive - Fertility -pre-implantation mortality (e.g. reduction in number of implants per femaletotal number of implants per corpora lutea)2.生殖毒性Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) 43 Reproductive Inhalation Rodent - rat 30 ppm/6H,male 65 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct 44 Reproductive Inhalation Rodent - rat 100 ppm/6H,female 6-17 day(s) after conception 1.生殖毒性Reproductive - Maternal Effects - parturition2.生殖毒性Reproductive - Fertility -female fertility index (e.g. # females pregnant per # sperm positive females# females pregnant per # femalesmated)3.生殖毒性Reproductive- Effects on Newborn -live birth index (measured after birth) 45 Reproductive Inhalation Rodent - rat 100 ppm/6H,female 6-17 day(s) after conception 1.生殖毒性Reproductive - Effects on Newborn -viability index (e.g., # alive at day 4 per # bornalive)2.生殖毒性Reproductive - Effects on Newborn -growth statistics (e.g.%, reduced weight gain) 46 Reproductive Inhalation Rodent - rat 30 ppm/6H,male 13 week(s) pre-mating 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) 47 Reproductive Administration onto the skin Rodent - rat 11592 mg/kg,female 6-17 day(s) after conception 1.生殖毒性Reproductive - Fertility -female fertility index (e.g. # females pregnant per # sperm positive females# females pregnant per # femalesmated)2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetaldeath 48 Reproductive Administration onto the skin Rodent - rat 4375 mg/kg,male 7 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, andcount)2.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct3.生殖毒性Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) 49 Reproductive Administration onto the skin Rodent - rat 2 mg/kg,female 10 day(s) after conception 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) 50 Reproductive Administration onto the skin Rodent - rat 1 mg/kg,female 12 day(s) after conception 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus)2.生殖毒性Reproductive - Specific Developmental Abnormalities -craniofacial (including nose andtongue)3.生殖毒性Reproductive - Specific Developmental Abnormalities -gastrointestinal system 51 Reproductive Intraperitoneal Rodent - rat 330 mg/kg,female 12 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system2.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system 52 Reproductive Intraperitoneal Rodent - rat 190 mg/kg,female 14 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System2.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system 53 Reproductive Intraperitoneal Rodent - rat 190 mg/kg,female 12 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 54 Reproductive Intraperitoneal Rodent - rat 190 mg/kg,female 8 day(s) after conception 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) 55 Reproductive Subcutaneous Rodent - rat 600 mg/kg,female 6-20 day(s) after conception 1.生殖毒性Reproductive- Effects on Newborn -live birth index (measured after birth)2.生殖毒性Reproductive - Effects on Newborn -viability index (e.g., # alive at day 4 per # bornalive) 56 Reproductive Subcutaneous Rodent - rat 440 mg/kg,female 7-17 day(s) after conception 1.生殖毒性Reproductive- Effects on Newborn -live birth index (measured after birth) 57 Reproductive Oral Rodent - rat 250 mg/kg,female 13 day(s) after conception 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus)2.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 58 Reproductive Oral Rodent - mouse 175 mg/kg,female 11 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 59 Reproductive Oral Rodent - mouse 2 mg/kg,female 7-14 day(s) after conception 1.生殖毒性Reproductive - Fertility -litter size (e.g. # fetuses per littermeasured before birth)2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetaldeath3.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System 60 Reproductive Oral Rodent - mouse 500 mg/kg,female 9 day(s) after conception 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)2.生殖毒性Reproductive - Fertility - litter size (e.g. # fetuses per littermeasured before birth)3.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 61 Reproductive Oral Rodent - mouse 250 mg/kg,female 11 day(s) after conception 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus)2.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 62 Reproductive Oral Rodent - mouse 6250 mg/kg,male 25 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct 63 Reproductive Inhalation Rodent - mouse 1000 ppm/6H,male 11 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct 64 Reproductive Inhalation Rodent - mouse 500 ppm/7H,male 5 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, andcount) 65 Reproductive Inhalation Rodent - mouse 50 ppm/6H,female 6-15 day(s) after conception 1.生殖毒性Reproductive - Fertility -litter size (e.g. # fetuses per littermeasured before birth)2.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system 66 Reproductive Inhalation Rodent - mouse 50 ppm/6H,female 6-15 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system2.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system 67 Reproductive Subcutaneous Rodent - mouse 1200 mg/kg,female 7-13 day(s) after conception 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 68 Reproductive Subcutaneous Rodent - mouse 3200 mg/kg,female 7-14 day(s) after conception 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) 69 Reproductive Subcutaneous Rodent - mouse 250 mg/kg,female 8 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System2.生殖毒性Reproductive - Specific Developmental Abnormalities -craniofacial (including nose andtongue) 70 Reproductive Intravenous Rodent - mouse 250 mg/kg,female 8 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities -Central Nervous System 71 Reproductive Oral Primate - monkey 930 mg/kg,female 20-45 day(s) after conception 1.生殖毒性Reproductive - Fertility -abortion2.生殖毒性Reproductive - Effects on Embryo or Fetus - fetaldeath 72 Reproductive Oral Primate - monkey 633 mg/kg,female 20-45 day(s) after conception 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus) 73 Reproductive Inhalation Rodent - rabbit 300 ppm/6H,male 65 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct 74 Reproductive Inhalation Rodent - rabbit 50 ppm/6H,female 6-18 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities -body wall2.生殖毒性Reproductive - Specific Developmental Abnormalities -cardiovascular (circulatory) system3.生殖毒性Reproductive - Specific Developmental Abnormalities -urogenital system 75 Reproductive Inhalation Rodent - rabbit 50 ppm/6H,female 6-18 day(s) after conception 1.生殖毒性Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stuntedfetus)2.生殖毒性Reproductive - Specific Developmental Abnormalities -body wall3.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 76 Reproductive Inhalation Rodent - rabbit 10 ppm/6H,female 6-18 day(s) after conception 1.生殖毒性Reproductive - Fertility -post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)2.生殖毒性Reproductive - Specific Developmental Abnormalities -musculoskeletal system 77 Reproductive Oral Rodent - guinea pig 6250 mg/kg,male 25 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct 78 Reproductive Administration onto the skin Rodent - guinea pig 65 mg/kg,male 65 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct 79 Reproductive Oral Rodent - hamster 1562 mg/kg,male 25 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - testes, epididymis, spermduct

二甲醚会中毒

二甲醚毒理学数据：

1、急性毒性：大鼠吸入LD5O：308mg/m2；

2、其他多剂量毒性：大鼠吸入TDLO：2pph/6H/30W-I；

3、吸入对中枢神经系统有抑制作用。吸入后可引起麻醉、窒息作用，麻醉作用比乙醚弱。对皮肤有刺激性。与空气混合能形成爆炸性混合物，在空气中允许浓度为400mg/kg。

4.急性毒性

LC50：308000mg/m2（大鼠吸入）

5.亚急性与慢性毒性 大鼠，吸入2%甲醚，每天6h，每周5d，30周，体重增加，血、尿及组织病理学检查均未见明显异常，但血清丙氨酸和天门冬氨酸和天门冬氨酸转氨酶增高，示有肝毒性。

扩展资料：

二甲醚的性质：

二甲醚是一种无色、具有轻微醚香味的气体，具有惰性、无致癌性但有神经毒性。

还具有优良的混溶性，能同大多数极性和非极性有机溶剂混溶。

在100ml水中可溶解3.700ml二甲醚气体，且二甲醚易溶于汽油、 四氯化碳、丙酮、氯苯和乙酸甲酯等多种有机溶剂，加入少量助剂后就可与水以任意比互溶。

其燃烧时火焰略带亮光。

参考资料来源：百度百科-二甲醚

二甲醚的毒性

健康危害

侵入途径：吸入

健康危害：对中枢神经系统有抑制作用，麻醉作用弱。吸入后可引起麻醉、窒息感。对皮肤有刺激性。

3.2毒理学资料及环境行为

毒性：二甲醚的毒性很低，气体有刺激及麻醉作用的特性，通过吸入或皮肤吸收过量的此物品，会引起麻醉，失去知觉和呼吸器官损伤。

表1.3

二甲醚的毒性

吸入对象

吸入量

不良反应

小鼠吸入

225.72g/

m3

麻醉浓度

猫吸入

1658.85g/

m3

深度麻醉

人吸入

154.24g/

m3×30min

轻度麻醉

人吸入

940.50g/

m3

有极不愉快的感觉、有窒息感

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Inc

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急性毒性：LC50308000mg/m3(大鼠吸入)；人吸入154.24g/m3×30分，轻度麻醉。

危险特性：易燃气体。与空气混合能形成爆炸性混合物。接触热、火星、火焰或氧化剂易燃烧爆炸。接触空气或在光照条件下可生成具有潜在爆炸危险性的过氧化物。气体比空气重，能在较低处扩散到相当远的地方，遇明火会引着回燃。若遇高热，容器内压增大，有开裂和爆炸的危险。

熔点-85°C，熔点-70℃。乙二醇和二乙二醇甲醚的溶解度分别是熔点-85°C和熔点-70℃。乙二醇也叫做甘醇，是一种无色无臭有甜味的液体，对动物来说有毒性。二乙二醇甲醚是一种化学物质，分子式是C5H12O3。

一：二甲苯和乙二醇常温下不溶，再加热的情况下互溶。二：二甲苯（dimethylbenzene）为无色透明液体；是苯环上两个氢被甲基取代的产物，存在邻、间、对三种异构体，在工业上，二甲苯即指上述异构体的混合物。二甲苯具刺激性气味、易燃，与乙醇、氯仿或乙醚能任意混合，在水中不溶。沸点为137～140℃。二甲苯毒性高等，美国政府工业卫生学家会议（ACGIH）将其归类为A4级，即缺乏对人体、动物致癌性证据的物质。、塑料、燃料、橡胶，各种涂料的添加剂以及各种胶粘剂、防水材料中，还可来自燃料和烟叶的燃烧气体。三：乙二醇（ethylene glycol）又名“甘醇”、“1,2-亚乙基二醇”，简称EG。化学式为(CH2OH)2，是最简单的二元醇。乙二醇是无色无臭、有甜味液体，对动物有毒性，人类致死剂量约为1.6 g/kg。乙二醇能与水、丙酮互溶，但在醚类中溶解度较小。用作溶剂、防冻剂以及合成涤纶的原料。乙二醇的高聚物聚乙二醇（PEG）是一种相转移催化剂，也用于细胞融合；其硝酸酯是一种炸药。