由苯合成间溴苯乙酸
以甲苯为原料。将甲苯用高锰酸钾氧化成苯甲酸,再用三氯化铁做催化剂与溴反应,生成3,5-二溴苯甲酸,然后将羧基用lialh4还原成羟甲基后用氯取代羟基,生成3,5-二溴苄氯,再在醇溶液中与氰化钠反应,产物水解后生成3,5-二溴苯乙酸。
等等,马上就好
先用酸性高锰酸钾氧化成苯甲酸,再与Br2~FeBr3反应,由于羧基是间位取代基,故生成间溴苯甲酸,反应机理为亲电取代再用氢化铝理还原为间溴苯甲醇,反应过程分两部,第一步是氢负离子的亲核酰基取代,生成间溴苯甲醛第二步是氢负离子的亲核加成,生成间溴苯甲醇,在与HBr溶液反应成间溴溴甲苯,接着将其与My在乙醚中反应生成格式试剂,反应机理为自由基反应,最后将格式试剂与CO2反应,即可生成间溴苯乙酸,反应机理为亲核加成(CO2可看成两个羰基,可与格式试剂发生亲核加成)。更详细的步骤与过程可参考北大版《基础有机化学》第三版上册(邢其毅主编)。
4 - (2 '(1' .3 '- dioxane E. Central - ethyl) benzene lithium borate
4,5 - difluoro of indole
4 - trifluoromethyl methoxy-benzonitrile
4 - trifluoromethyl benzene borate
4 - methoxy-2 - nitroaniline
4 --2 - Dinitrotoluene
4 - hydroxymethyl -5 - methyl -2 - phenyl oxazolidine
4 - Nitro -3 - acetaminophen - trifluoromethyl benzene
4 - Nitro -3 --- trifluoromethyl benzene
4 - bromine -5 - fluoride -2 - Dinitrotoluene
4 - iodine benzenesulfonyl chloride
4 - sodium iodobenzene
5 - oxidation of methyl indole
5 - Oxygen indole -2 - carboxylate
5 - Chlorine 2 - 4-anisidine
5 - chlorine -2 - methoxy-bromophenyl
5 - chlorine -2 - fluorophenyl carbonitrile
5 - chlorine indole
5 - chlorine indole -2 - carboxylic acid ethyl
5 - cyano-2 - fluorophenyl formaldehyde
5 - nitro-indole -2 - carboxylate
5 - nitro-indole -2 - carboxylic acid ethyl
6 - fluoride pyridine -2 - carboxylate
6 - chlorine -3 - fluoride -2 - methylpyridine
6 - chlorine indole -2 - carboxylic acid ethyl
L-tyrosine tert-Butyl
N-(2 - chlorine -5 - methyl) pyridyl phthalimide
N-(3 - fluoride -4 - Nitro) benzyl MORPHOLINO
N-methyl - N-(2 - chlorine -4 - amino)-piperazine
N-methyl - N-(2 - chlorine -4 - nitro-phenyl)-piperazine
Glycol shrink -5 - fluoro-4 - Hydroxy-3 - Nitro E aldehyde
Trifluoromethyl acetyl-acetonitrile
Pyruvic acid p-chlorophenyl hydrazone
Right - (1,3 - Central E-dioxane) Bromobenzene
P acetanilide
The dinitrophenylhydrazine
The dinitrophenylhydrazine
Ethyl 4-nitrophenyl hydrazone
Esters of nitrobenzene hydrazone
Of Bromoxynil
The formylphenyl phenyl methacrylate
Pharmaceutical intermediates directory:
Indole -2 - carboxylic acid ethyl
O hydroxymethyl benzene borate
O-phenyl acid aldehyde
Inter-ethoxy-pentyl酰aniline
Inter-ethoxy-pentyl酰aniline
Inter-pyridyl-phenyl sulfone A sulfonate
Inter-pentyl aroylamino phenyl acid pentyl ester
Inter-pentyl phenyl acid amide
Toluene between bromine
Inter-bromophenyl B cyanide
Inter-bromo phenylacetate
Inter-p-Bromobenzylbromide
Thiophenyl acetonitrile
Diazotization on fluoride
Sylvite
O-allyl two carbamoyl tertiary amine
B.乙醛中含-CHO,则乙醛发生氧化反应一步转化为乙酸,故B不选;
C.卤代烃发生消去反应生成烯烃,则溴乙烷在NaOH/醇中加热一步转化为乙烯,故C不选;
C.苯与液溴反应生成溴苯,可发生取代反应一步转化,故D不选;
故选A.